Genetic determination of antibody specificity |
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Authors: | N. Hilschmann H. U. Barnikol H. Kratzin P. Altevogt M. Engelhard S. Barnikol-Watanabe |
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Affiliation: | 1. Max-Planck-Institut für experimentelle Medizin, D-3400, G?ttingen
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Abstract: | The best system for the study of cell differentiation is a cell which in its differentiated state differs only by one product. This is the case in the immune system. The undifferentiated, but omnipotent stem cell differentiates into a committed B cell which produces only one type of specific antibody out of a million different, genetically fixed possibilities. Gene translocation and fusion is the basis of this differentiation process. |
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