| Metabolism of benzo[a]pyrene in peroxynitrite/Fe（Ⅲ） porphyrin system |
| |
| 作者姓名： | LUO Yun-jing LIN Tai-feng ZHANG Shu-fen LIU Rui ZHONG Ru-gang |
| |
| 作者单位： | College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China. |
| |
| 基金项目： | Project supported by the Beijing Natural Science Foundation （No. 2052004）, the Beijing Nova Programme （No. 2003B05） and the National Natural Science Foundation of China （No. 20605002）. |
| |
| 摘 要： | The peroxynitrite/porphyrin biomimetic system was established to investigate the effects of peroxynitrite on benzoa]pyrene （Ba]P） metabolism. Three model systems consisting of different iron porphyrins were compared, and the results showed that the peroxynitdte/T（p-Cl）PPFeCl system was the highest catalytic efficiency in the metabolism of B a]P. We analyzed the B a]P metabolites produced from this system by RP-HPLC method and firstly identified the formation of nitrobenzoa]pyrenes which are the special metabolites of B a]P induced by peroxynitrite.
|
| 关 键 词： | 过亚硝酸盐/铁卟啉系统 苯并[a]吡 代谢 转化 环境污染物 细胞毒性 |
| 收稿时间： | 2006-11-08 |
| 修稿时间： | 2007-01-04 |
Metabolism of benzo[a]pyrene in peroxynitrite/Fe(III) porphyrin system. |
| |
| LUO Yun-jing LIN Tai-feng ZHANG Shu-fen LIU Rui ZHONG Ru-gang.Metabolism of benzo[a]pyrene in peroxynitrite/Fe(III) porphyrin system.[J].Journal of Environmental Sciences,2007,19(4):385-386. |
| |
| Authors: | LUO Yun-jing LIN Tai-feng ZHANG Shu-fen LIU Rui ZHONG Ru-gang |
| |
| Institution: | College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China. luoyj@bjut.edu.cn |
| |
| Abstract: | The peroxynitrite/porphyrin biomimetic system was established to investigate the effects of peroxynitrite on benzoa]pyrene (Ba]P) metabolism. Through the comparison of three model systems consisting of different iron porphyrins, we found that the peroxynitrite/T(p-Cl)PPFeCl system showed the highest catalytic efficiency in the metabolism of Ba]P. We analyzed the Ba]P metabolites produced from this system by RP-HPLC method and firstly identified the formation of nitrobenzoa]pyrenes which are the special metabolites of Ba]P induced by peroxynitrite. |
| |
| Keywords: | peroxynitrite benzo[a]pyrene metabolism nitrobenzo[a]pyrenes |
| 本文献已被 维普 等数据库收录！ |
