Umbilical cord blood PBDEs concentrations are associated with placental DNA methylation |
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| Institution: | 1. Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai, China;2. CITIC Medical & Health Group, Beijing, China;3. Department of Health Management, Jiangxi University of Traditional Chinese Medicine, China;4. Obstetrics & Gynecology Hospital, Fudan University, Shanghai, China;5. State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Tongji University, Shanghai, China;1. Nicholas School of the Environment, Duke University, Durham, NC, USA;2. Department of Statistics, Rice University, Houston, TX, USA;1. Unit of Molecular Cancer Epidemiology, Universitary Institute of Oncology of the Principality of Asturias (IUOPA), Spain;2. Department of Preventive Medicine and Public Health, University of Oviedo, Julián Clavería, s/n, 33006 Oviedo, Asturias, Spain;3. Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDÆA-CSIC), Jordi Girona, 18, 08034 Barcelona, Catalonia, Spain;4. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Melchor Fernández Almagro, 3-5, 28029, Madrid, Spain;1. Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University, Shanghai, China;2. MOE and Shanghai Key Laboratory of Children''s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;3. Research Base of Key Laboratory of Surveillance and Early Warning on Infection Disease in China CDC, Shanghai, Pudong New Area Center for Disease Control and Prevention, China;4. Department of Pediatrics, Dongfang Hospital, Tongji University, Shanghai, China;5. College of Life and Environmental Sciences, Minzu University of China, Beijing, China |
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| Abstract: | BackgroundIn utero polybrominated diphenyl ethers (PBDEs) exposure has been associated with adverse fetal growth. Alterations in placental DNA methylation might mediate those adverse effects.ObjectivesTo examine the associations between in utero PBDEs exposure and DNA methylation in human placenta.MethodsEighty apparently healthy mother-newborn pairs delivering at the Second Affiliated Hospital of Wenzhou Medical College were enrolled in this study. Placental DNA methylation of LINE1, NR3C1 and IGF2 was measured by quantitative polymerase chain reaction-pyrosequencing. In utero PBDEs exposure was assessed by measuring umbilical cord blood PBDEs concentrations.ResultsFor LINE-1, higher levels of BDE-66 exposure were associated with decreased DNA methylation (β = ? 0.9, 95% CI, ? 1.8 to ? 0.1); For NR3C1, BDE-153 concentrations was significantly inversely associated with DNA methylation (β = ? 2.0, 95% CI, ? 3.7 to ? 0.2); For IGF2, elevated concentrations of both BDE-153 (β = ? 1.7; 95% CI, ? 3.0 to ? 0.4) and BDE-209 (β = ? 1.0; 95% CI, ? 1. 9 to ? 0.1) were significantly associated with decreased DNA methylation.ConclusionsWe found that placental DNA methylation is associated with in utero PBDEs exposure. Changes in placental DNA methylation might be part of the underlying biological pathway between in utero PBDEs exposure and adverse fetal growth. |
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