Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health |
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| Institution: | 1. Center for Environmental Health and Sciences, Hokkaido University, Sapporo, Japan;2. Department of Urology, Hokkaido University Hospital, Sapporo, Japan;3. Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan;4. Department of Obstetrics and Genecology, Hokkaido University Hospital, Sapporo, Japan;5. Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan;6. Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan;7. Kushiro Rosai Hospital, Kushiro, Japan;1. Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan;2. Department of Occupational Therapy, School of Sciences, Sapporo Medical University, Sapporo, Japan;3. Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan;4. Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan;1. ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain;2. Universitat Pompeu Fabra (UPF), Barcelona, Spain;3. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;4. Epidemiology and Environmental Health Joint Research Unit, FISABIO–Universitat Jaume I–Universitat de València, Valencia, Spain;5. Subdirección de Salud Pública y Adicciones de Gipuzkoa, Donostia-San Sebastián, Spain;6. Instituto de Investigación Sanitaria BIODONOSTIA, Donostia-San Sebastián, Spain;7. Facultad de Psicología, Universidad del País Vasco (UPV/EHU), Donostia-San Sebastián, Spain;8. Institute for Occupational Medicine, RWTH Aachen University, Aachen, Germany;1. MOE-Shanghai Key Laboratory of Children''s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China;2. School of Public Health, Guilin Medical University, Guilin 541004, Guangxi, China;1. Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China;2. Department of Epidemiology, College for Public Health and Social Justice, Saint Louis University, Saint Louis 63104, USA;3. School of Social Work, College for Public Health and Social Justice, Saint Louis University, Saint Louis 63104, USA;4. Department of Chemistry, Université de Montréal, Montreal, QC H3C 3J7, Canada;5. Faculty of Health, School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia;6. Department of Epidemiology and Biostatistics, School of Public Health, State University of New York, Albany, NY 12144-3445, USA;7. Liwan District Maternal and Child Health Hospital, Guangzhou 510375, China;8. Zhejiang Chinese Medical University, Hangzhou 310053, China;9. Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China |
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| Abstract: | BackgroundExposure to perfluoroalkyl substances (PFASs) may disrupt reproductive function in animals and humans. Although PFASs can cross the human placental barrier, few studies evaluated the effects of prenatal PFAS exposure on the fetus' reproductive hormones.ObjectiveTo explore the associations of prenatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) with cord blood reproductive hormones.MethodsIn the prospective birth cohort (Sapporo cohort of the Hokkaido study), we included 189 mother–infant pairs recruited in 2002–2005 with both prenatal maternal and cord blood samples. PFOS and PFOA levels in maternal blood after the second trimester were measured via liquid chromatography–tandem mass spectrometry. We also measured cord blood levels of the fetuses' reproductive hormones, including estradiol (E2), total testosterone (T), progesterone (P4), inhibin B, insulin-like factor 3, steroid hormone binding globulin, follicle-stimulating hormone, and luteinizing hormone, and prolactin (PRL).ResultsThe median PFOS and PFOA levels in maternal serum were 5.2 ng/mL and 1.4 ng/mL, respectively. In the fully adjusted linear regression analyses of the male infants, maternal PFOS levels were significantly associated with E2 and positively, and T/E2, P4, and inhibin B inversely; PFOA levels were positively associated with inhibin B levels. Among the female infants, there were significant inverse associations between PFOS levels and P4 and PRL levels, although there were no significant associations between PFOA levels and the female infants' reproductive hormone levels.ConclusionsThese results suggest that the fetal synthesis and secretion of reproductive hormones may be affected by in utero exposure to measurable levels of PFOS and PFOA. |
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