Traffic-related air pollution and hyperactivity/inattention,dyslexia and dyscalculia in adolescents of the German GINIplus and LISAplus birth cohorts |
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| Institution: | 1. ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain;2. Universitat Pompeu Fabra (UPF), Barcelona, Spain;3. CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain;4. Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany;5. Research Institute, Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany;6. Division of Metabolic and Nutritional Medicine, Dr von Hauner Children''s Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany;7. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilian University of Munich, Munich, Germany;8. IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany;9. Ludwig-Maximilians-University, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany;1. Faculty of Medicine, University of the Basque Country (UPV/EHU), Leioa, Basque Country, Spain;2. BIODONOSTIA Health Research Institute, San Sebastian, Basque Country, Spain;3. Department of Statistics, Informatics and Applications “G. Parenti”, University of Florence, Italy;4. Biostatistics Unit, Cancer Prevention and Research Institute (ISPO), Florence, Italy;5. Faculty of Psychology, University of the Basque Country UPV/EHU, San Sebastian, Basque Country, Spain;6. Department of the Environment and Regional Planning, Government of the Basque Country, Vitoria, Spain;7. Public Health Laboratory, Department of Health, Government of the Basque Country, Bilbao, Spain;8. Sub-Directorate for Public Health of Guipúzcoa, Department of Health, Government of the Basque Country, San Sebastian, Spain;9. Biomedical Research Centre Network for Epidemiology and Public Health (CIBERESP), Spain;1. ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia 08003, Spain;2. Pompeu Fabra University, Barcelona, Catalonia 08003, Spain;3. Spanish Consortium for Research and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid 28029, Spain;4. Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia 08003, Spain;5. Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre–Sophia Children''s Hospital, Rotterdam 3015CN, The Netherlands;6. Faculty of Psychology, University of the Basque Country UPV/EHU, San Sebastian 20080, Spain;7. Instituto de Investigación Sanitaria Biodonostia, San Sebastián, Basque Country 20014, Spain;8. Epidemiology and Environmental Health Joint Research Unit, FISABIO–Universitat Jaume I–Universitat de València, Valencia 46020, Spain;9. IUOPA-Preventive Medicine and Public Health, Department of Medicine, University of Oviedo, Asturias 33006, Spain;10. Subdirección de Salud Pública y Adicciones de Guipúzkoa, San Sebastián 20013, Spain;11. Departamento de Medicina Preventiva y Salud Pública, University of the Basque Country UPV/EHU, San Sebastian 20014, Spain;12. Preventive Medicine and Public Health Training Unit, Parc de Salut Mar - Pompeu Fabra University - Public Health Agency of Barcelona, Spain;1. Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA;2. Channing Laboratory, Brigham and Women''s Hospital, Boston, MA, USA;3. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA;4. Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA;5. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA;6. Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece;7. The Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel;8. Department of Neurology, Boston Children''s Hospital, Harvard Medical School, Boston, MA, USA;9. Division of Newborn Medicine, Boston Children''s Hospital, Harvard Medical School, Boston, MA, USA;10. Center for Environmental Research and Children''s Health, School of Public Health, University of California at Berkeley, Berkeley, CA, USA;1. Kravis Children''s Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA;2. Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA;3. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA;4. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA;5. Department of Neurology Research, Children''s Hospital Boston, Harvard Medical School, Boston, MA, USA;6. Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Israel;7. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA;8. The Mindich Child Health & Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA |
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| Abstract: | BackgroundFew studies have examined the link between air pollution exposure and behavioural problems and learning disorders during late childhood and adolescence.ObjectivesTo determine whether traffic-related air pollution exposure is associated with hyperactivity/inattention, dyslexia and dyscalculia up to age 15 years using the German GINIplus and LISAplus birth cohorts (recruitment 1995–1999).MethodsHyperactivity/inattention was assessed using the German parent-completed (10 years) and self-completed (15 years) Strengths and Difficulties Questionnaire. Responses were categorized into normal versus borderline/abnormal. Parent-reported dyslexia and dyscalculia (yes/no) at age 10 and 15 years were defined using parent-completed questionnaires. Individual-level annual average estimates of nitrogen dioxide (NO2), particulate matter (PM)10 mass, PM2.5 mass and PM2.5 absorbance concentrations were assigned to each participant's birth, 10 year and 15 year home address. Longitudinal associations between the air pollutants and the neurodevelopmental outcomes were assessed using generalized estimation equations, separately for both study areas, and combined in a random-effects meta-analysis. Odds ratios and 95% confidence intervals are given per interquartile range increase in pollutant concentration.ResultsThe prevalence of abnormal/borderline hyperactivity/inattention scores and parental-reported dyslexia and dyscalculia at 15 years of age was 12.9%, 10.5% and 3.4%, respectively, in the combined population (N = 4745). In the meta- analysis, hyperactivity/inattention was associated with PM2.5 mass estimated to the 10 and 15 year addresses (1.12 1.01, 1.23] and 1.11 1.01, 1.22]) and PM2.5 absorbance estimated to the 10 and 15 year addresses (1.14 1.05, 1.25] and 1.13 1.04, 1.23], respectively).ConclusionsWe report associations suggesting a potential link between air pollution exposure and hyperactivity/inattention scores, although these findings require replication. |
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