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Preimplantation genetic diagnosis (PGD), a collaborative activity of clinical genetic departments and IVF centres |
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| Authors: | Joep P M Geraedts Joyce Harper Peter Braude Karen Sermon Anna Veiga Luca Gianaroli Noelle Agan Santiago Munné Sue Gitlin Elisabeth Blenow Kylie de Boer Nicole Hussey Emmanuel Kanavakis Soo-Huan Lee Stéphane Viville Lewis Krey Pierre Ray Serena Emiliani Yung Hsien Liu Stefan Vermeulen |
| Institution: | 1. Research Institute Growth and Development, Universiteit Maastricht, The Netherlands;2. Departement of Obstetrics and Gynaecology, University College London, London, UK;3. Assisted Conception Unit, St Thomas Hospital, London, UK;4. Centre for Medical Genetics, Free Brussels University (VUB), Brussels, Belgium;5. Instituto Dexeus, Barcelona, Spain;6. SISMER, Bologna, Italy;7. Department of Obstetrics and Gynaecology, Baylor College of Medicine, Houston, TX, USA;8. Institute for Reproductive Medicine and Science, St Barnabas Medical Center, West Orange, NJ, USA;9. Jones Institute for Reproductive Medicine, Norfolk, VI, USA;10. Deptartment of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden;11. Sydney IVF, Sydney, Australia;12. Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia;13. First Department of Pediatrics, Sophia's Children's Hospital, Athens, Greece;14. Cha General Hospital, Pochon Cha University, Seoul, Korea;15. Service de la Biologie de la Reproduction, Strasbourg, France;16. New York University Medical Center, New York, NY, USA;17. Hopital Necker, Paris, France;18. ULB Erasme, Brussels, Belgium;19. Centre for Reproductive Medicine, Kaohsiung, Taiwan;20. Centre for Medical Genetics, Gent, Belgium |
| Abstract: | An Erratum has been published for this article in Prenatal Diagnosis 22 (5) 2002, 451. Preimplantation genetic diagnosis (PGD) requires the combined efforts of geneticists and workers in the field of reproductive medicine. This was studied on the basis of a questionnaire, sent to 35 members of the PGD Consortium of the European Society of Human Reproduction and Embryology (ESHRE). A reply was obtained from 20 centres. They represent the majority of activities in the field of PGD in the world. It is obvious that many of the activities (in vitro fertilisation, embryo culture and biopsy) take place in IVF units while others (counselling and diagnosis) are the responsibility of genetic diagnostic centres. The distances between both units vary considerably. In all but one centre sex determination is offered. Aneuploidy screening is offered in 13 out of 20 centres. PGD of translocations and other structural chromosome abnormalities is offered in all but one centre. The number of monogenic diseases offered varies considerably. In comparison to prenatal diagnosis PGD is more expensive. The majority of these costs are due to the IVF or ICSI procedure. The charges for PGD vary between about € 600 and € 4000. In 16 out of 20 centres the parents to be must sign an informed consent form. Copyright © 2001 John Wiley & Sons, Ltd. |
| Keywords: | preimplantation genetic diagnosis (PGD) in vitro fertilisation (IVF) intracytoplasmatic sperm injection (ICSI) PCR FISH |