Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan;2. Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan;3. Department of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan;4. Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan;5. Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan;6. Department of Computer Science and Engineering, College of Informatics, Yuan Ze University, Chungli, Tao-Yuan, Taiwan