Evaluation on subcellular partitioning and biodynamics of pulse copper toxicity in tilapia reveals impacts of a major environmental disturbance |
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Authors: | Yun-Ru Ju Ying-Fei Yang Jeng-Wei Tsai Yi-Hsien Cheng Wei-Yu Chen Chung-Min Liao |
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Institution: | 1.Department of Marine Environmental Engineering,National Kaohsiung Marine University,Kaohsiung,Republic of China;2.Department of Bioenvironmental Systems Engineering,National Taiwan University,Taipei,Republic of China;3.Department of Biological Science and Technology,China Medical University,Taichung,Taiwan;4.Institute of Computational Comparative Medicine, Department of Anatomy and Physiology,Kansas State University,Manhattan,USA;5.Department of Biomedical Science and Environmental Biology,Kaohsiung Medical University,Kaohsiung,Republic of China |
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Abstract: | Fluctuation exposure of trace metal copper (Cu) is ubiquitous in aquatic environments. The purpose of this study was to investigate the impacts of chronically pulsed exposure on biodynamics and subcellular partitioning of Cu in freshwater tilapia (Oreochromis mossambicus). Long-term 28-day pulsed Cu exposure experiments were performed to explore subcellular partitioning and toxicokinetics/toxicodynamics of Cu in tilapia. Subcellular partitioning linking with a metal influx scheme was used to estimate detoxification and elimination rates. A biotic ligand model-based damage assessment model was used to take into account environmental effects and biological mechanisms of Cu toxicity. We demonstrated that the probability causing 50% of susceptibility risk in response to pulse Cu exposure in generic Taiwan aquaculture ponds was ~33% of Cu in adverse physiologically associated, metabolically active pool, implicating no significant susceptibility risk for tilapia. We suggest that our integrated ecotoxicological models linking chronic exposure measurements with subcellular partitioning can facilitate a risk assessment framework that provides a predictive tool for preventive susceptibility reduction strategies for freshwater fish exposed to pulse metal stressors. |
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