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Interaction of different forms of graphene with chicken embryo red blood cells
Authors:Sławomir Jaworski  Mateusz Hinzmann  Ewa Sawosz  Marta Grodzik  Marta Kutwin  Mateusz Wierzbicki  Barbara Strojny  Krishna P. Vadalasetty  Ludwika Lipińska  André Chwalibog
Affiliation:1.Faculty of Animal Science, Department of Animal Nutrition and Biotechnology,Warsaw University of Life Sciences,Warsaw,Poland;2.Department of Veterinary Clinical and Animal Sciences,University of Copenhagen,Copenhagen,Denmark;3.Institute of Electronic Materials Technology,Warsaw,Poland
Abstract:With the rapid development of graphene synthesis and functionalization approaches, graphene and its related derivatives have shown great potential in many applications in material science, including biomedical applications. Several in vitro and in vivo studies clearly showed no definitive risks, while others have indicated that graphene might become health hazards. In this study, we explore the biocompatibility of graphene-related materials with chicken embryo red blood cells (RBC). The hemolysis assay was employed to evaluate the in vitro blood compatibility of reduced graphene, graphene oxide, and reduced graphene oxide, because these materials have recently been used for biomedical applications, including injectable graphene-related particles. This study investigated structural damage, ROS production and hemolysis of chicken embryo red blood cells. Different forms of graphene, when incubated with chicken embryo RBC, were harmful to cell structure and induced hemolysis.
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