Temporal - and dose-related characteristics of biochemical and morphological alterations in the hamster induced by 2,3,7,8-tetrachlorodibenzo-
-dioxin |
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Authors: | Thomas A Gasiewicz Ellen C Henry Raymond B Baggs George Rucci Arnold Schecter |
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Institution: | Thomas A. Gasiewicz*, Ellen C. Henry, Raymond B. Baggs, George Rucci,Arnold Schecter |
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Abstract: | The temporal - and dose-related characteristics of hepatic enzymes induced and toxic responses elicited in the hamster by 2,3,7,8-tetrachlorodibenzo-
-dioxin were examined. The results demonstrate a dissociation of the induction of these hepatic enzymes from TCDD-elicited lethality, but not necessarily hepatic damage, in this species. Furthermore, the hyperthyroidism observed is suggestive of a role of these hormones in the relatively insensitive nature of this species to TCDD treatment. |
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