Towards a multidisciplinary and integrated strategy in the assessment of adverse health effects related to air pollution: the case study of Cracow (Poland) and asthma |
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Authors: | Oudinet Jean-Paul Méline Julie Che?micki Wojciech Sanak Marek Magdalena Dutsch-Wicherek Besancenot Jean-Pierre Wicherek Stanislas Julien-Laferrière Bertrand Gilg Jean-Paul Geroyannis Hélène Szczeklik Andrew Krzemień Kazimierz |
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Institution: | Centre de Biogéographie-Ecologie FRE 2545 CNRS, Maison de la recherche, Université Paris-Sorbonne, Paris IV, 28 rue Serpente, 75006 Paris, France. biogeo@paris4.sorbonne.fr |
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Abstract: | Complex interaction between anthropogenic activities, air quality and human health in urban areas, such as in Cracow sustains the need for the development of an interdisciplinary and integrated risk-assessment methodology. In such purpose, we propose a pilot study performed on asthmatics and based on a combined use of a biomarker, such as metallothionein 2A (MT-2A) in the characterization of human exposure to one or a mixture of pollutants and of Geographical Information Systems (G.I.S.) which integrates climatic and urban anthropogenic parameters in the assessment of spatio-temporal dispersion of air pollutants. Considering global incidence of air pollution on asthma and on peripheral blood lymphocytes MT-2A expression should provide a complementary information on biological risks linked to urban anthropogenic activities. Such study would help for the establishment of a sustainable development in urban areas that can maintain the integrity of air quality and preserve human health. |
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