Adverse effects in wild fish living downstream from pharmaceutical manufacture discharges |
| |
Authors: | Sanchez Wilfried Sremski William Piccini Benjamin Palluel Olivier Maillot-Maréchal Emmanuelle Betoulle Stéphane Jaffal Ali Aït-Aïssa Sélim Brion François Thybaud Eric Hinfray Nathalie Porcher Jean-Marc |
| |
Affiliation: | Institut National de l'Environnement Industriel et des Risques (INERIS), Unité d'Ecotoxicologie in vitro et in vivo, Verneuil-en-Halatte, France. Wilfried.Sanchez@ineris.fr |
| |
Abstract: | A set of biochemical and histological responses was measured in wild gudgeon collected upstream and downstream of urban and pharmaceutical manufacture effluents. These individual end-points were associated to fish assemblage characterisation. Responses of biotransformation enzymes, neurotoxicity and endocrine disruption biomarkers revealed contamination of investigated stream by a mixture of pollutants. Fish from sampled sites downstream of the industrial effluent exhibited also strong signs of endocrine disruption including vitellogenin induction, intersex and male-biased sex-ratio. These individual effects were associated to a decrease of density and a lack of sensitive fish species. This evidence supports the hypothesis that pharmaceutical compounds discharged in stream are involved in recorded endocrine disruption effects and fish population disturbances and threaten disappearance of resident fish species. Overall, this study gives argument for the utilisation of an effect-based monitoring approach to assess impacts of pharmaceutical manufacture discharges on wild fish populations. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|