Metabolic conversion of 14C-chloralkylene - 9

¹⁴C-Chloralkylene-9 was applied to rats for 35 days (2 ppm/day/animal)². GC-Mass Spectra indicated oxygenated components of chloralkylene-9 in urine and feces. The urinary metabolites were characterized to be mono-, di- and trihydroxy 2,4′-dichlorobiphenyls. The feces contained mainly those metabolites in which the side chain of mono-, di- and tri-isopropyl 2,4′-dichlorobiphenyl was oxidized. Different metabolic products containing alcoholic, aldehydic and carboxylic side chains were detected. Metabolites with unsaturated side chains were also detected.The GC-Mass spectroscopic analysis of chloroalkylene-9 residue showed the major component consisted of di- and tri-isopropyl 2,4′-dichlorobiphenyl. 2,4′-dichlorobiphenyl and monoisopropyl 2,4′-dichlorobiphenyl were found to comprise a smaller percentage of the total residue. There was also an indication of isomerization of 2,4′-dichlorobiphenyl.