Studies on transitory laxative effects of sorbitol and maltitol: III: Alterations in serum contents due to laxative effects |
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Authors: | N Koizumi M Fujii R Ninomiya Y Inoue T Kagawa T Tsukamoto |
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Institution: | 1. Department of Public Health, Hyogo College of Medicine, Hyogo, Japan;7. Food Chemistry Division, Environmental Health Bureau, Ministry of Health and Welfare, Tokyo, Japan |
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Abstract: | Maltitol or sorbitol was administered in doses of 0.8 g/kg to 20 physically healthy subjects (10 males and 10 females) and 6 diabetic patients (3 males and 3 females). Maltitol and sorbitol caused diarrhea in 75% and 95% of the subjects, respectively. Stool was watery in most of the subjects. The serum concentration of each sweetening agent was as low as approximately 0.3 mg/dl 2 hours after administration. The serum concentrations of Na, K, Cl, BUN, glucose and insulin did not change 2 hours after administration. |
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