Metabolism of bis-methylthiotetrachlorobenzene in rats |
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Authors: | J.E. Bakke |
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Affiliation: | Metabolism and Radiation Research Laboratory Agricultural Research Service U. S. Department of Agriculture Fargo, ND 58105 USA |
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Abstract: | Oral doses of bis-methylthiotetrachlorobenzene (bis-MTTCB) given to control rats and rats with cannulated bile ducts showed that at least 50% of the dose, although excreted mainly as bis-MTTCB in the feces, was metabolized. The metabolism involved replacement of one of the methylthio groups with glutathione, biliary excretion of the mercapturic acid pathway metabolites, and subsequent reformation of bis-MTTCB which is excreted with the feces. |
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