Novative Biomaterials Based on Chitosan and Poly(ε-Caprolactone): Elaboration of Porous Structures |
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Authors: | Verónica P Martino Eric Pollet Luc Avérous |
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Institution: | 1.LIPHT-ECPM, EAc CNRS 4379,Université de Strasbourg,Strasbourg Cedex 2,France |
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Abstract: | The swelling capability of chitosan was explored in order to use water both, as volatile plasticizer and as pore-forming agent.
Chitosan powder was swelled in acidic aqueous solution and melt blended with poly(ε-caprolactone) (PCL). After stabilization
at 57% RH and 25 °C, samples suffered a water mass loss of around 30 wt% without dimensions variation. Despite the low miscibility
of these biopolymers, quite homogeneous dispersion of chitosan within the polyester matrix was obtained. Some interactions
between both biopolymers could be observed. To obtain chitosan phase with a thermoplastic-like behaviour, the plasticization
effect was also studied by the addition of 25 wt% glycerol as non volatile plasticizer. The equilibrium moisture content of
samples increased with the incorporation of glycerol due to its hydrophilic nature. Morphology, thermal and mechanical properties
of the blends were determined after stabilization. The preparation of rich PCL blends allowed the formation of macroporous
structures since samples were not contracted after water loss and stabilization. These biomaterials with such a porous structure
could be used for biomedical applications. |
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