| QuEChERS-超高效液相色谱-串联质谱法测定鱼血清中的精神活性物质 |
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| 引用本文： | 王泽远,杨方星.QuEChERS-超高效液相色谱-串联质谱法测定鱼血清中的精神活性物质[J].环境化学,2022,41(1):205-214. |
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| 作者姓名： | 王泽远 杨方星 |
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| 作者单位： | 浙江大学环境与资源学院污染环境修复与生态健康教育部重点实验室,杭州,310058 |
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| 基金项目： | 国家自然科学基金(41977341)资助~~； |
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| 摘 要： | 本文建立了一种同时测定鱼血清中19种精神活性物质的分析方法.该方法基于QuEChERS方法对样品进行提取和净化,待测物采用超高效液相色谱-串联质谱法(UPLC-MS/MS)进行分析,检测的19种精神活性物质均采用同位素内标法定量.该方法的方法检测限(MDL)范围为0.02-0.06 ng.mE-1,基质效应处于76.7...
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| 关 键 词： | 精神活性物质 血清 鱼 QuEChERS 液相色谱-串联质谱 |
Simultaneous determination of psychoactive substances in fish serum by QuEChERS and ultra-high performance liquid chromatography coupled with tandem mass spectrometry |
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| WANG Zeyuan,YANG Fangxing.Simultaneous determination of psychoactive substances in fish serum by QuEChERS and ultra-high performance liquid chromatography coupled with tandem mass spectrometry[J].Environmental Chemistry,2022,41(1):205-214. |
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| Authors: | WANG Zeyuan YANG Fangxing |
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| Institution: | (Key Laboratory of Environment Remediation and Ecological Health,Ministry of Education,College of Environmental&Resourse Sciences,Zhejiang University,Hangzhou,310058,China) |
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| Abstract: | A method was developed to simultaneously detect 19 psychoactive substances in fish serum.The serum was extracted and purified by QuEChERS,and then analyzed by ultra-high performance liquid chromatography coupled with tandem mass spectrometry(UPLC-MS/MS).The method detection limits(MDLs)were in the range of 0.02 ng·mL?1 to 0.06 ng·mL-1.The matrix effects were between 76.7%and 127.7%.The relative recoveries ranged from 81.1%to 123.9%with the relative standard deviations of method≥18.0%.The method has been successfully employed to analyze the 19 psychoactive substances in serums of Crucian carp(Carassius carassius). |
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| Keywords: | psychoactive substances serum fish QuEChERS liquid chromatography-tandem mass spectrometry |
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