Investigation of drugs of abuse and relevant metabolites in Dutch sewage water by liquid chromatography coupled to high resolution mass spectrometry |
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| Affiliation: | 1. Institute of Chemical and Environmental Engineering, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia;2. Institute of Biochemistry, Nutrition and Health Protection, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia;3. Institute of Natural and Synthetic Polymers, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia;4. University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zatisi 728/II, 389 01 Vodnany, Czech Republic;1. Department of Environment, University of the Aegean, University Hill, Mytilene 81 100, Greece;2. Toxicological Center, Department of Pharmaceutical Sciences, Campus Drie Eiken, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium;3. Department of Environmental Health Sciences, IRCCS – Istituto di Ricerche Farmacologiche “Mario Negri”, 16 Via La Masa 19, 20156 Milan, Italy;1. The University of Queensland, The National Research Centre for Environmental Toxicology (Entox), 39 Kessels Road, Coopers Plains, QLD 4108, Australia;2. School of Psychology, University of Tasmania, Private Bag 30, Hobart, TAS 7001, Australia;3. The University of Queensland, Centre for Clinical Research, Brisbane, QLD 4000, Australia;4. Faculty of Law, University of Tasmania, Australia;5. School of Chemical and Physical Sciences, Flinders University, Adelaide, SA 5001, Australia;6. International Laboratory for Air Quality and Health, Queensland University of Technology, Brisbane, QLD 4000, Australia;7. Queensland Health Forensic Scientific Services, Queensland Government, 39 Kessels Road, Coopers Plains, QLD 4108, Australia;8. Eastern Health Clinical School, Monash University, Melbourne, VIC 3000, Australia;9. Turning Point, Eastern Health, Melbourne, VIC 3000, Australia;10. National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2031, Australia;1. Water and Soil Quality Research Group, Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain;2. Catalan Institute for Water Research (ICRA), Parc Científic i Tecnològic de la Universitat de Girona, Edifici H2O, Emili Grahit 101, 17003 Girona, Spain |
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| Abstract: | An extensive study on the presence of illicit drugs and pharmaceuticals with potential for abuse in sewage waters was made for the first time in the Netherlands. A total number of 24 target drugs were investigated in influent and effluent wastewater using liquid chromatography coupled to a high resolution Orbitrap mass spectrometer. This powerful analyzer has allowed not only the detection and identification of the compounds under investigation, but also their quantification at very low levels, which is highly innovative in the field of drugs of abuse. Samples were taken from five sewage treatment plants (STPs) during a whole week. The selected STPs served four cities of different size and an international airport. Daily variances of drug loads were demonstrated and removal efficiencies calculated for each drug and STP individually. Twelve target compounds were found in at least one influent or effluent, and highest concentrations were observed in influents collected from more urbanized areas. The compounds more frequently detected were amphetamine, benzoylecgonine, cocaine and THC COOH together with the pharmaceuticals codeine, oxazepam and temazepam. Established week trends in consumption of drugs showed distinct differences between individual drugs. A slightly different occurrence pattern was observed in wastewaters from the airport. Thus, methamphetamine was only detected at Schiphol, a fact that was interpreted to be caused by consumption of this drug by travelers. Despite the fact that the Netherlands has frequently been criticized for its liberal drug policy the results from this study did not reveal higher drug consumption than found elsewhere, with the exception of cannabis. |
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