Effect of acute nitrogen dioxide exposure on the composition of fatty acid associated with phospholipids in alveolar lavage |
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| Authors: | Takahiro Kobayashi Tadashi Noguchi Masataka Kikuno Kentaro Kubota |
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| Institution: | 1. Division of Basic Medical Sciences, The National Institute for Environmental Studies, Tsukuba, Ibaraki 305, Japan;2. Division of Toxicity Testing, Japan Industrial Safety Association, Shiba 5-35-Minato-ku, Tokyo 102, Japan;3. Department of Chemistry, Sophia University, Kioi-cho-7, Chiyoda-ku, Tokyo 102, Japan |
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| Abstract: | In vivo exposure of rats to 10 ppm nitrogen dioxide (NO2) for 12h caused changes in fatty acids composition of alveolar lavage phospholipids. Among the fatty acid species, the relative ratio of palmitic acid, myristic acid and palmitoleic acid increased significantly. While the relative ratio of stearic acid, oleic acid, linoleic acid and arachidonic acid decreased significantly. Both the increase in the incorporation of palmitic acid in phosphatidylcholine which would be released into the alveoli and the increase in the release of phosphatidylcholine into the alveoli may account for the changes in the fatty acid composition of the present findings. |
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