柳叶忍冬的化学成分研究

从柳叶忍冬95%乙醇提取物中首次分离并鉴定了20个化合物: ( )-cycloolivil (1)、( )-fraxiresinol (2)、prinsepiol(3)、软脂酸(4)、对甲基苯酚(5)、2,4-二羟基-3,6-二甲基苯甲酸甲酯(6)、洋芹素(7)、木犀草素(8)、5,7,4′-三羟基黄酮醇7-O-β-D-吡喃葡萄糖苷(9)、槲皮素(10)、染料木素(11)、5,4′-二羟基-7-甲氧基异黄酮(12)、染料木素5-O-β-D-吡喃葡萄糖苷(13)、5,4′-二羟基-7-甲氧基异黄酮5-O-β-D-吡喃葡萄糖苷(14)、5,7,4′-三羟基双氢黄酮7-O-β-D-吡喃葡萄糖苷(15)、丁二酸(16)、( )-儿茶素(17)、( -)-表儿茶素(18)、谷甾醇(19)和胡萝卜苷(20).应用波谱方法及与已知品对照进行结构鉴定.其中,化合物10、17和18是抑制血管紧张素转化酶的活性成分.表4参63

Chemical Study on the Stem of Lonicera landeolata

Twenty compounds were obtained for the first time from the 95%-ethanol extract of the stems of Lonicera landeolata Wall. In Roxb. They were identified as (+)-cycloolivil (1), (+)-fraxiresinol (2), prinsepiol (3), palmitic acid (4), 4-methylphenol (5), methyl 2,4-dihydroxy-3,6-dimethylbenzoate (6), apigenin (7), luteolin (8), 5,7,4′-trihydroxyflavonol 7-O-β-D-glucopyranoside (9), quercetin (10), genistein (11), prunetin (12), genistein 5-O-β-D-glucopyranoside (13), prunetin 5-O-β-D-glucopyranoside (14), 5,7,4′-trihydroxyflavanone 7-O-β-D-glucopyranoside (15), succinic acid (16), (+)-catechin (17), (-)-epicatechin (18), β-sitosterol (19) and β-daucosterol (20). Their structures were determined by spectroscopic methods or comparison with authentic samples. Among them, compounds 10, 17 and 18 were the ACEI active constituents. Tab 4, Ref 63