The Experimental Research (In Vitro) of Carrageenans and Fucoidans to Decrease Activity of Hantavirus |
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| Authors: | Stanislav N Pavliga Galina G Kompanets Vasiliy Yu Tsygankov |
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| Institution: | 1.School of Natural Sciences,Far Eastern Federal University (FEFU),Vladivostok,Russia;2.School of Biomedicine,Far Eastern Federal University (FEFU),Vladivostok,Russia;3.Somov Research Institute of Epidemiology and Microbiology,Vladivostok,Russia |
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| Abstract: | The effect of carrageenans and fucoidans on the activity of Hantavirus is studied. It has been found that among carrageenans a significant antiviral effect is exerted by the ι-type, which decreases the viral titer by 2.5 log focus forming units per mL; among fucoidans, by a preparation from Laminaria cichorioides, which reduces the number of infected cells from 27.0 to 5.3 after pretreatment of both the macrophage culture and Hantavirus. The antiviral effect of fucoidan from Laminaria japonica is shown to grow in direct proportion to the increase of dose of the preparation. |
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