Principles and application of an in vivo swine assay for the determination of arsenic bioavailability in contaminated matrices |
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| Authors: | Matthew Rees Lloyd Sansom Allan Rofe Albert L Juhasz Euan Smith John Weber Ravi Naidu and Tim Kuchel |
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| Institution: | (1) Institute for Medical and Veterinary Science, Frome Road, Adelaide, SA, 5000, Australia;(2) Sansom Institute, School of Pharmacy and Medical Sciences, Division of Health Science, University of South Australia, City East Campus, Adelaide, SA, 5001, Australia;(3) Centre for Environmental Risk Assessment and Remediation, Division of Information Technology, Engineering and the Environment, University of South Australia, Mawson Lakes Campus, Mawson Lakes, SA, 5095, Australia;(4) Present address: Cooperative Research Centre for Contamination Assessment and Remediation of the Environment, Mawson Lakes, SA, 5095, Australia |
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| Abstract: | The assessment of arsenic (As) bioavailability from contaminated matrices is a crucial parameter for reducing the uncertainty
when estimating exposure for human health risk assessment. In vivo assessment of As utilising swine is considered an appropriate
model for human health risk assessment applications as swine are remarkably similar to humans in terms of physiology and As
metabolism. While limited in vivo As bioavailability data is available in the literature, few details have been provided regarding
technical considerations for performing in vivo assays. This paper describes, with examples, surgical, experimental design
and analytical issues associated with performing chronic and acute in vivo swine assays to determine As bioavailability in
contaminated soil and food. |
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