A Novel Biodegradable Green Poly(l-Aspartic Acid-Citric Acid) Copolymer for Antimicrobial Applications |
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| Authors: | N Mithil Kumar K Varaprasad K Madhusudana Rao A Suresh Babu M Srinivasulu S Venkata Naidu |
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| Institution: | (1) Synthetic Polymer Laboratory-II, Department of Polymer Science & Technology, Sri Krishnadevaraya University, Anantapur, 515055, Andhra Pradesh, India;(2) Synthetic Polymer Laboratory-I, Department of Polymer Science & Technology, Sri Krishnadevaraya University, Anantapur, 515055, Andhra Pradesh, India;(3) Ion Exchange (IND) Ltd, Hyderabad, Andhra Pradesh, India;(4) Department of Physics, Rayalaseema University, Karnool, 518002, Andhra Pradesh, India;(5) Department of Microbiology, Sri Krishnadevaraya University, Anantapur, 515055, Andhra Pradesh, India |
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| Abstract: | Poly (l-aspartic acid-citric acid) green copolymers were developed using thermal polymerization of aspartic acid (ASP) and citric
acid (CA) followed by direct bulk melt condensation technique. Antibacterial properties of copolymer of aspartic acid based
were investigated as a function of citric acid content. This study is focused on the microorganism inhibition performance
of aspartic acid based copolymers. Results showed that inhibition properties increase with increasing citric acid content.
Characterization of obtained copolymers was carried out with the help of infrared absorption spectra (FTIR), x-ray diffraction
(XRD), differential scanning calorimetry (DSC) and thermo gravimetric analysis (TGA). The antibacterial activity of copolymers
against bacteria like E-coli, Bacillus and pseudomonas was investigated. The copolymers showed excellent antimicrobial activities
against three types of microorganisms. Overall studies indicated that the above copolymers possess a broad wound dressing
activity against above three types of bacteria and may be useful as antibacterial agents. |
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