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Prenatal exclusion of duchenne muscular dystrophy by fetal muscle biopsy |
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| Authors: | Professor R J Benzie P Ray D Thompson A G W Hunter B Iwey L Salvador |
| Institution: | 1. Division of Molecular Genetics, Hospital for Sick Children, University of Toronto, Toronto, Canada;2. Division of Genetics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa Canada;3. Division of Perinatology, Department of Obstetrics and Gynaecology, University of Ottawa, Ottawa, Canada |
| Abstract: | A fetal thigh muscle biopsy was performed at 18 weeks and 6 days' gestation using an automatic 18-gauge biopsy needle. A positive immunoreaction with antisera to the amino- and carboxy-terminals of dystrophin excluded Duchenne muscular dystrophy from this at-risk male. |
| Keywords: | Duchenne muscular dystrophy in utero muscle biopsy prenatal diagnosis |