A fetus with a parvovirus B19 infection and congenital anomalies |
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| Authors: | R G Tiessen A M W van Elsacker-Niele Chr Vermeij-Keers D Oepkes J van Roosmalen M C B Gorsira |
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| Institution: | 1. Department of Anatomy, Erasmus University Rotterdam, Rotterdam, The Netherlands;2. Departments of Virology, University of Leiden, Leiden, The Netherlands;3. Gynaecology and Obstetrics, University of Leiden, Leiden, The Netherlands;4. Pathology, University of Leiden, Leiden, The Netherlands |
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| Abstract: | A fetus with multiple structural defects was seen at prenatal ultrasound examination. After termination of the pregnancy a bilateral cleft lip, alveolus, and palate; micrognathia; and webbed joints were seen. Fetal tissues showed indications of infection, intranuclear inclusion bodies, chronic stress, haemolysis, arterial wall damage, and profuse haemorrhage. Parvovirus B19 DNA was detected in fetal tissues by dot hybridization after polymerase chain reaction. The possibility of parvovirus B19 infection leading to congenital malformations is discussed. |
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| Keywords: | Parvovirus B19 intrauterine ultrasound diagnosis bilateral cleft lip and palate intranuclear bodies |
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