Prenatal diagnosis of alpha-1-antitrypsin deficiency by PCR of linked polymorphisms: A study of 17 cases |
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| Authors: | C M Abbott J U Lovegrove D B Whitehouse D A Hopkinson S Povey |
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| Institution: | MRC Human Biochemical Genetics Unit, Galton Laboratory, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, U.K. |
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| Abstract: | We describe our experiences of prenatal diagnosis of alpha-1-antitrypsin deficiency using closely linked polymorphisms detected by Southern blotting and the polymerase chain reaction. Prenatal diagnosis was carried out for 17 pregnancies from 15 couples. |
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| Keywords: | Alpha-1-antitrypsin CVS PCR |
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