Evaluation of transcervical chorionic villus sampling with a completed follow-up of 1550 consecutive pregnancies |
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Authors: | M G J Jahoda MD L Pijpers A Reuss F J Los J W Wladimiroff E S Sachs |
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Institution: | 1. Departments of Obstetrics and Gynecology, Erasmus University, Rotterdam, The Netherlands;2. Clinical Genetics, University Hospital ‘Dijkzigt’, Erasmus University, Rotterdam, The Netherlands |
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Abstract: | Data from 1550 consecutive pregnancies after first-trimester prenatal diagnosis by transcervical chorionic villus sampling (TC-CVS) are presented. The sampling efficacy was 97.8 per cent; the mean amount of collected villus tissue was 23 mg (range 5–100 mg). There were 97 affected fetuses, mainly (73.2 per cent) with a chromosomal abnormality or a male karyotype in carriers of X-linked disease. Pregnancy termination in these and four other women for social reasons resulted in 1449 continuing pregnancies. In these pregnancies, the fetal loss rate up to 28 weeks of gestation was 5.1 per cent with the highest loss rate (3.9 per cent) before 16 weeks. When relating this fetal loss rate to maternal age, this was 6.1 per cent in the advanced maternal age group (?36 years) against 3.1 per cent in the younger age group. In 1376 pregnancies continuing beyond 28 weeks, the perinatal mortality rate was 1.1 per cent; the percentage of non-genetic congenital anomalies was 0.9 per cent. The reproductive pattern of women at high genetic risk after CVS followed by pregnancy termination was evaluated. Within 12 months after the first CVS followed by pregnancy termination, 70 percent of women again requested CVS in a subsequent pregnancy. |
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Keywords: | Transcervical CVS Abortion risk Follow-up Acceptability of CVS |
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