Prenatal diagnosis of bartter syndrome |
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| Authors: | H Shalev M Ohaly I Meizner R Carmi MD |
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| Institution: | 1. Pediatric Division, The Soroka Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva;2. The Department of Pediatrics, Barzilai Medical Center, Ashkelon, Israel;3. Obstetrics and Gynecology Division—Sonography Unit, The Soroka Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva |
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| Abstract: | Bartter syndrome, an autosomal recessive disorder of hyperaldosteronism and increased plasma renin, was suspected in an at-risk pregnancy due to the early occurrence of polyhydramnios. Further establishment of the diagnosis was accomplished by demonstrating increased levels of aldosterone in amniotic fluid and fetal cord blood. Electrolyte levels did not differ significantly from reported controls. It is thus suggested that polyhydramnios is the result of increased fetal urine output in Bartter syndrome and that amniotic fluid aldosterone is a reliable marker for the prenatal diagnosis of this condition. |
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| Keywords: | Bartter syndrome polyhydramnios aldosterone prenatal diagnosis |
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