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Early genetic amniocentesis and its relationship to respiratory difficulties in paediatric patients: A report of findings in patients and matched controls 3–5 years post-procedure |
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| Authors: | Byron C Calhoun Walter Brehm Allan T Bombard MD |
| Institution: | Department of Obstetrics and Gynecology, Keesler Medical Center, Biloxi, Mississipi, U.S.A.
Division of Reproductive Genetics, Department of Obstetrics and Gynecology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, U.S.A. |
| Abstract: | This study evaluates the long-term pulmonary complications of 25 children from a prospective, matched-control, pilot study evaluating short-term complications of early (11–14 weeks' gestation) versus traditional (15 weeks' gestation and later) genetic amniocentesis. Five children in the early amniocentesis group were found to have various respiratory difficulties, a morbidity rate comparable to that of paediatric patients in the general population. These data identify the need for larger, multicentre trials. |
| Keywords: | Prenatal diagnosis early amniocentesis pulmonary disease |