Application of fluorescent in situ hybridization for ‘de novo’ anomalies in prenatal diagnosis |
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| Authors: | D. Van Opstal H. J. Eussen J. O. Van Hemel E. S. Sachs |
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| Affiliation: | Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands |
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| Abstract: | Fluorescent in situ Hybridization (FISH) was carried out for three cases of abnormal karyotypes in prenatal studies. Two concerned de novo structural anomalies and the third a marker chromosome. The origin of the extra material could be defined in all three cases, which gives a better insight into the relationship between genotype and phenotype and makes more adequate genetic counselling possible. |
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| Keywords: | Prenatal diagnosis In situ hybridization Markers |
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