首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Autosomal recessive polycystic kidney disease. Problems of prenatal diagnosis
Authors:Dr med K Zerres  M Hansmann  R Mallmann  U Gembruch
Institution:1. Universitäts-Frauenklinik Bonn, Bonn, F.R.G.;2. Universitäts-Kinderklinik Bonn, Bonn, F.R.G.
Abstract:Autosomal recessive polycystic kidney disease (ARPKD) is characterized by different proportions of cystic dilated collecting ducts invariably associated with congenital hepatic fibrosis. Because of the nearly regular arrangement of nephrons and collecting ducts, disturbances have been postulated to act rather late on embryological grounds. Prenatal diagnoses seem to confirm this observation, as can be demonstrated in our cases and those reported in the literature. Increased echogenicity and renal enlargement are the main ultrasonographic signs of ARPKD; oligohydramnios is characteristic but not always present. Repeated sono-graphic measurements of the kidney length seem to be the most useful parameter. As differential diagnoses, autosomal dominant polycystic kidney disease as well as Meckel syndrome have to be taken into consideration. The prognosis of cases with oligohydramnios is usually poor. In genetic counselling, the possibility of prenatal diagnosis in the second trimester of pregnancy should be given with caution.
Keywords:Autosomal recessive  polycystic kidney disease  Ultrasound  prenatal diagnosis
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号