PRENATAL DIAGNOSIS OF CYSTIC HYGROMA AND CHORIOANGIOMA IN THE WOLF-HIRSCHHORN SYNDROME |
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| Authors: | Dr A Verloes J P Schaaps C Kerens D Soyeur J Hustin P Dodinval |
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| Institution: | 1. Prenatal Diagnosis Unit, Gynecology-Obstetrks Department, Liège University, Belgium;2. Centre for Human Genetics, Liège University, Belgium;3. Service of Cardiology, Medicine Department, Liège University, Belgium;4. Institute for Morphologic Pathology, Loverval, Belgium |
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| Abstract: | We report the prenatal diagnosis of Wolf-Hirschhorn syndrome (4p –) in a 24-week-old fetus. Echographic features included cystic hygroma, a complex heart defect with right ventricular hypoplasia, and a large placental chorioangioma. We suggest that chorioangioma may be associated with chromosomal imbalance and that systematic careful morphologic examination of the fetus and karyotyping of any pregnancy in which large chorioangioma is detected is advisable. Jugular lymphatic obstruction sequence has not been reported so far in association with 4p– syndrome. |
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| Keywords: | Chorioangioma Cystic hygroma Monosomy4p Prenatal diagnosis Wolf-Hirschhorn syndrome |
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