Chorionic villus sampling for prenatal diagnosis in wales using DNA probes—5 years' experience |
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Authors: | Meena Upadhyaya Alan Fryer Graham Foat Denise Robinson Oliver Quarrell Adrian Roberts P S Harper |
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Institution: | 1. Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, U.K.;2. Department of Obstetrics and Gynaecology, University Hospital of Wales, Heath Park, Cardiff CF4 4XW, U.K. |
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Abstract: | Chorionic villi were sampled from 125 women who requested prenatal diagnosis, either for genetic disorders or because of advanced maternal age. Of these, 105 samples were obtained by the transcervical route and 20 were obtained by the transabdominal approach. The sampling success rate was 97 per cent (122/125). The mean maternal age of the patients was 31 years (range 17–44) and the mean gestational age at which the chorionic villus sampling was performed was 10 weeks (range 7–13 weeks). Seventy-four of these diagnoses involved the use of DNA markers. The minimal size of the sample used for DNA diagnosis was 5 mg. Maternal contamination was detected in two samples. A diagnosis was provided on all but two samples. The fetal loss rate was high initially but fell to 1·9 per cent in 1988. |
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Keywords: | Chorionic villus sampling DNA Prenatal diagnosis |
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