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First-trimester screening for fetal chromosomal abnormalities. Preliminary results |
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| Authors: | J M M van Lith |
| Institution: | 1. Department of Obstetrics and Gynaecology, University Hospital Groningen, Oostersingel 59, 9713 EZ Groningen, The Netherlands
Participating prenatal diagnostic centres: University Hospital Groningen;2. A. Mantingh;3. Rijnstate Hospital Arnhem;4. M. D. Kloosterman;5. Academic Medical Centre Amsterdam;6. H. Wolf;7. University Hospital Leiden;8. H. H. H. Kanhai;9. Medical spectrm Twente Enschede;10. E. Everhardt;11. University Hospital Utrecht;12. G. C. M. L. Chistiaens;13. Free University Hospital Amsterdam;14. J. M. G. Van Vugt;15. Laboratories, University hospital Groningen;16. H. W. A. De Bruijn, J. J. Pratt. |
| Abstract: | We have started a multicentre trial to study the possibilities of first-trimester maternal serum screening for fetal chromosomal abnormalities. Maternal blood samples were obtained before 13 weeks of gestation. We present the preliminary results of the first 950 patients on alpha-fetoprotein (AFP). Results on cancer antigen 125 (CA 125) in Down's syndrome and normal pregnancies are also presented. We conclude that the results on AFP are promising and that CA 125 might be predictive for fetal Down's syndrome. |
| Keywords: | First trimester Down's syndrome Autosomal trisomy Alpha-fetoprotein CA 125 |