Triploid fetus: An important consideration in the evaluation of very high maternal serum alpha-fetoprotein |
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| Authors: | Lillian C Kazazian Theodore A Baramki Ronald L Thomas |
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| Institution: | Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A. |
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| Abstract: | Two patients referred for evaluation of very high maternal serum alpha-fetoprotein (10–20 multiples of the median) were carrying triploid fetuses with placentas showing features of partial hydatidiform mole. The diagnosis of fetal triploidy should be considered when there is a very high maternal serum alpha-fetoprotein and no ultrasound evidence of open neural tube defect, ventral wall defect, or any other explanation. Therefore, chromosomal analysis of amniotic fluid cells in such cases is essential. |
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| Keywords: | Alpha-fetoprotein Triploidy Prenatal diagnosis |
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