Fetal diagnosis of toxoplasmosis in 190 women infected during pregnancy |
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Authors: | Francine Pratlong Pierre Boulot Eric Issert Martine Msika Frédéric Dupont Bruno Bachelard Pierre Sarda Jean-Louis Viala Daniel Jarry |
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Institution: | 1. Laboratoire de Parasitologie—Mycologie, 163 Rue Auguste Broussonnet, 34059 Montpellier, France;2. Fetal Medicine Unit, Département de Gynécologie et Obstétrique, Hǒpital Arnaud de Villeneuve, 34059 Montpellier, France;3. Service de Pédiatrie néonatale, Hǒpital Arnaud de Villeneuve, 34059 Montpellier, France |
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Abstract: | One hundred and ninety women who contracted toxoplasmosis after the seventh week of pregnancy underwent antenatal diagnosis, including ultrasound examination and biological tests. Tests included Toxoplasma isolation in fetal blood and amniotic fluid by mouse inoculation, specific IgM and IgA in fetal blood, and non-specific tests. Twenty fetuses had positive specific as well as non-specific tests for Toxoplasma infection. At birth, four of these presented with clinical congenital toxoplasmosis and 12 with subclinical forms. Antenatal diagnosis enabled the detection of 83 per cent of the infected fetuses. Under specific conditions, cordocentesis permits early diagnosis and considerably reduces the number of terminations of pregnancy. |
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Keywords: | Congenital toxoplasmosis cordocentesis specific IgA prenatal diagnosis fetal infection |
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