Prenatal diagnosis and postnatal follow-up of a child with two de novo unrelated balanced reciprocal translocations |
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| Authors: | M Pruggmayer B Zoll M Leipoldt U Thies |
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| Institution: | 1. Institut für Humangenetik, Universität Göttingen, F.R.G.;2. Abteilung für Klinische Genetik, Univ. Tübingen, F.R.G. |
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| Abstract: | Two unrelated, apparently balanced, reciprocal translocations involving chromosomes 3 and 17, and 10 and 15 were found in cultured amniotic fluid cells from a 41-year-old 10-gravida. Chromosome analysis of peripheral blood lymphocytes of both parents revealed normal katryotypes. Post-partum examination of lymphocyte cultures from the proband confirmed the chromosome rearrangements. The child showed normal development during follow-up examinations up to the age of 4 years. |
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| Keywords: | Complex chromosome rearrangement De novo Prenatal diagnosis Postnatal confirmation |
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