| 2-萘胺的代谢及其活化机理的研究 |
| |
| 引用本文： | 李廷书,戴天有,戴乾圆,裴淑.2-萘胺的代谢及其活化机理的研究[J].环境科学学报,1990,10(4):401-406. |
| |
| 作者姓名： | 李廷书 戴天有 戴乾圆 裴淑 |
| |
| 作者单位： | 北京工业大学化学与环境工程学系，北京工业大学化学与环境工程学系，北京工业大学化学与环境工程学系，北京市劳动卫生职业病研究所 研究生 中国环境监测总站 |
| |
| 基金项目： | 国家自然科学基金资助项目 |
| |
| 摘 要： | 经诱导的大鼠肝微粒体S9制剂与2-萘胺一起培养,代谢产物经鉴定有以下4种:2-氨基—5-萘酚,2-氨基—6-萘酚,2-氨基—7萘酚和2-氨基—8-萘酚,其生成数量不等.2-萘胺的8-,5-,6-和7-位酚的相对含量依次为52.6％,28.5％,14.0％和4.9％.上述的比例与用双区理论计算和推导的结果是一致的,表明在代谢中芳胺的氨基与异环碳皆起着活化与脱毒的双重作用.
|
| 关 键 词： | 2－萘胺 代谢 活化 双区理论 污染物 |
| 收稿时间： | 1989/9/30 0:00:00 |
STUDIES ON METABOLISM OF 2-NAPHTHYLAMINE AND ITS ACTIVATION MECHANISM |
| |
| Li Tingshu,Dai Tianyou,Dai Qianhuan and Pei Shu.STUDIES ON METABOLISM OF 2-NAPHTHYLAMINE AND ITS ACTIVATION MECHANISM[J].Acta Scientiae Circumstantiae,1990,10(4):401-406. |
| |
| Authors: | Li Tingshu Dai Tianyou Dai Qianhuan and Pei Shu |
| |
| Institution: | Department of Chemistry & Environmental Engineering, Beijing Polytechnic University,Department of Chemistry & Environmental Engineering, Beijing Polytechnic University,Department of Chemistry & Environmental Engineering, Beijing Polytechnic University and Beijing Institute of Labor Hygiene find Occupational Diseases |
| |
| Abstract: | After incubation of 2-naphthylamine with induced rat liver microsome S9 preparation,the metabolites were isolated by using HPLC and identified as 2-amino8-naphthol(52.6%), 2-amino-5-naphthol(28.5%), 2-amino-6-naphthol(14.0%)and 2-amino-7-naphthol(4.9%). The measured results are same as those calculated by quantitative HMO based on Di-region theory. Both amino group and carbon atoms on the extra-ring play duality roles of activation and detoxification in metabolism. |
| |
| Keywords: | 2-naphthylamine metabolism 2-aminonaphthols Di-region theory |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《环境科学学报》浏览原始摘要信息 |
| 点击此处可从《环境科学学报》下载免费的PDF全文 |
|
