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Efficient synthesis of 2-(thiocyanomethylthio)benzothiazole
Institution:1. Central Leather Research Institute, Adyar, Madras 600 020, India;2. National Chemical Laboratory, Pune 411 008, India;1. Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, CauGiay, Hanoi, Vietnam;2. SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium;1. Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan;2. Center for Research and Education on Drug Discovery, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan;3. Graduate School of Pharmaceutical Sciences, University of Shizuoka, Yada, Shizuoka 422-8526, Japan;4. Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan;3. From the Department of Biochemistry and Center of Excellence in Protein Structure and Function, Faculty of Science, Mahidol University, Bangkok, Thailand 10400, the;4. Department of Biochemistry, Faculty of Science, Burapha University, Chonburi, Thailand 20131, the;5. Department of Biochemistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand 10300, the;6. Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, and the;1. Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, Japan;2. Laboratory of Bioorganic Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, Japan;1. Department of Chemistry, Organic Chemistry I, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany;2. Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong
Abstract:In the leather industry phenolic-based fungicides have been in use until recently. As a result of legislation limiting the content of pentachlorophenol (PCP) in leather, non-chlorophenolics based on 2-(thiocyanomethylthio)benzothiazole (TCMTB) have become more widely used in the leather industry for controlling the growth of fungi and sulphate-reducing bacteria. This paper reports a clean and simple method of synthesis of TCMTB, which is characterized by conventional methods, IR, 1H NMR and mass spectral data.
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