Alterations in some renal parameters of rats induced by aqueous soil extracts |
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| Authors: | Flavio Manoel Rodrigues da Silva Jr Ana Luíza Muccillo-Baisch |
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| Affiliation: | 1. Laboratório de Ensaios Farmacológicos e Toxicológicos, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande – FURG, Rio Grande, Brazil flaviorodrigues@furg.br;3. Laboratório de Ensaios Farmacológicos e Toxicológicos, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande – FURG, Rio Grande, Brazil |
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| Abstract: | Soil ingestion can be an important route of exposure to contaminants present in the environment. This study examined the effects of exposure to contaminants in aqueous soil extracts from an industrial urban settlement in renal biochemical parameters of treated rats. Male Wistar rats were gavaged with an aqueous soil extract, from the municipality of Rio Grande, Southern Brazil. After exposure, plasma and urine concentrations and plasma protein were assessed compared to rats treated with aqueous soil from relatively unpolluted site (control soil). There was increase in plasma creatinine and total protein in urine, and a decreased glomerular filtration rate in treated rats compared to control. It is possible that Cd, Cr, As, Cu, Pb, Zn, and Ni analyzed in the soil samples and unidentified components may have provoked the observed changes in renal biochemistry of the exposed rat. This may suggest that exposure to contaminated soils can cause damage to the viscera in mammals and it is of public health importance. |
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| Keywords: | creatinine soil ingestion renal toxicity water-soluble elements |
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