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Hydroxyl radical generation and oxidative stress in Carassius auratus exposed to glyphosate and its formulation
Authors:Jinyu Fan  Hongqiang Ren  Xiaorong Wang
Institution:State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China
Abstract:Oxidative stress parameters and some antioxidant defense systems in the liver of Carassius auratus exposed to glyphosate and its formulation (Roundup®) have been studied. Fish were exposed to glyphosate and its formulation at concentrations of 0.032, 0.16, 0.8, and 4.0 mg L?1, all calculated on glyphosate basis, for 11 days. Hydroxyl radical generation as determined by electron spin resonance spectroscopy of its spin-adduct with α-phenyl-t-butyl nitrone increased with the concentration of Roundup®. Superoxide dismutase activities were decreased relative to control by 21%–46% when exposed to glyphosate and 45%–52% when exposed to Roundup®, suggesting that the formulation is more toxic than glyphosate alone. Catalase showed no difference between both groups.
Keywords:Carassius auratus  glyphosate  Roundup®  hydroxyl radical (·OH)  antioxidant defenses
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