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In vitro genotoxicity of extracellular extract from Nostoc piscinale |
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| Authors: | Eshrat Gharaei-Fathabad Mojtaba Tabatabaei Yazdi Seyed-Nasser Ostad Mohammad Ali Faramarzi |
| Affiliation: | 1. Faculty of Pharmacy, Department of Pharmacognosy and Biotechnology , Mazandaran University of Medical Sciences , Sari 48175/861, Iran e_gharaee@yahoo.com;3. Faculty of Pharmacy, Biotechnology Research Center, Department of Pharmaceutical Biotechnology , Medical Sciences, University of Tehran , Tehran, 14174, Iran;4. Faculty of Pharmacy, Medicinal Plant Research Center, Department of Toxicology and Pharmacology , Medical Sciences, University of Tehran , Tehran, 141155, Iran |
| Abstract: | The extracellular extract obtained from 3 weeks incubation of the soil isolate cyanobacterium strain Nostoc piscinale GT-319 in BG-11 broth medium showed cytotoxic activity against Chinese Hamster Ovary (CHO) cells. Based on comet assay, a concentration of 333 µg mL?1 (IC50) produced DNA breakages in CHO cells. The concentration of 481 mg kg?1 (LD50) produced acute toxicity in mice at 48 h. |
| Keywords: | Nostoc piscinale acute toxicity comet assay genotoxicity |