Repeated-dose toxicity attributed to aluminum nanoparticles following 28-day oral administration,particularly on gene expression in mouse brain |
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Authors: | Eun-Jung Park Hero Kim Younghun Kim Kyunghee Choi |
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Institution: | 1. College of Pharmacy, Dongduk Women's University , 23-1, Wolgok-dong, Seongbuk-gu, Seoul 136-714 , Korea pej303@korea.kr;3. Department of Chemical Engineering , Kwangwoon University , 447-1 Wolgye-dong, Nowon-gu, Seoul 139-701 , Korea;4. Environmental Health Risk Research Department , National Institute of Environmental Research , Kyungseo-dong , Seo-gu, Incheon 404-708 , Korea |
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Abstract: | Nanotechnology is a rapidly growing industry that has elicited much concern due to the lack of available toxicity data. Aluminum oxide nanoparticles (AlNP) were listed as a high-priority group in the Organization for Economic Co-operation and Development (OECD) Steering Group for Test Guidelines. In this study, AlNP 35 ± 18.8 nm in size were administered daily at doses of 15, 30, or 60 mg k?1 for 28 days. A significant decrease in white blood cells (WBC), neutrophils, lymphocytes, and monocytes was observed in the group treated with 60 mg kg?1 of AlNP, accompanied by a significant increase in platelets. The concentration of aluminum (Al) rose significantly in the thymus, lung, and brain of the group treated with 60 mg kg?1 of AlNP. However, no significant changes in histopathology were observed. The expression for feeding behavior, energy expenditure, and neurodegeneration-related genes were up-regulated more than twofold by 60 mg kg?1 AlNP. Consequently, data suggest that exposure to AlNP may result in adverse health effects, including but not limited to growth inhibition, immunosuppression, and neurodegeneration. |
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Keywords: | aluminum oxide nanoparticle hematology brain microarray neurodegeneration |
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