Microbiological evaluation of 4-(6-chloro-7H-purin-8-ylamino)-3-nitro-chromen-2-one with a comparison to antibacterial activity of standard drugs |
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| Authors: | Sevdije Govori Arben Haziri |
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| Affiliation: | 1. Department of Chemistry, Faculty of Natural Sciences, University of Pristina, Pristina, Republic of Kosovosevdije.govori@uni-pr.edu;3. Department of Chemistry, Faculty of Natural Sciences, University of Pristina, Pristina, Republic of Kosovo |
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| Abstract: | Nucleophilic substitution of 4-chloro-3-nitro-2-oxo-2H-chromen-2-one 3 by 6-chloro-7H-purin-2-ylamine (a), yielded the corresponding 4-(6-chloro-7H-purin-8-ylamino)-3-nitro-chromen-2-one 4. The chemical structure of synthesized compound was characterized using IR and NMR spectra, and elemental analyses. The purified synthesized compound 4 was tested at concentrations 1, 3, 5 mg/ml for its antibacterial activity against three bacterial cultures: Staphylococcus aureus, Escherichia coli, and Bacillus cereus. The antibacterial activity of synthesized compound was compared to antibacterial activity of standard antibiotics cephalexine and streptomycin. |
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| Keywords: | 4-(6-chloro-7H-purin-8-ylamino)-3-nitro-chromen-2-one synthesis antibacterial activity Staphylococcus aureus Escherichia coli Bacillus cereus cephalexine streptomycin |
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