White blood cell sister chromatid exchange among a sample of Thai subjects exposed to lead: Lead-induced genotoxicity |
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| Authors: | Viroj Wiwanitkit Jamsai Suwansaksri Suphan Soogarun |
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| Institution: | 1. Department of Laboratory Medicine , Faculty of Medicine , Chulalongkorn University, Bangkok 10330, Thailand wviroj@yahoo.com;3. Department of Clinical Chemistry , Faculty of Allied Health Sciences , Chulalongkorn University, Bangkok 10330, Thailand;4. Department of Clinical Microscopy , Faculty of Allied Health Sciences , Chulalongkorn University, Bangkok 10330, Thailand |
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| Abstract: | Epidemiological and experimental studies indicated that inorganic lead compounds are associated with increased risks of tumorigenesis. This study was aimed at determination for sister chromatid exchange (SCE), a marker for genotoxicity with correlation to lead blood levels in Thai exposed subjects. A total of 32 police (all males) were included into this study. The average (mean ± SD) blood lead in these police was 2.1 ± 1 µmol L?1. The average SCE among the police with high blood lead was significant higher than those with low metal exposure. Data suggest that cytogenetic response to Pb is significantly different between the subjects with high versus low lead exposure. High exposure to lead seems related to high chromosome aberrations. |
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| Keywords: | lead SCE |
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