In vitro assessment of genotoxic and oxidative effects of zinc borate |
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| Authors: | Fatih Ça?lar Çelikezen Hasan Türkez Ba?ak To?ar |
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| Institution: | 1. Department of Chemistry, Faculty of Science and Letters, Bitlis Eren University, Bitlis, Turkeyccelikezen@beu.edu.tr;3. Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, Turkey;4. Department of Pharmacy, “G. D’Annunzio” University, Chieti, Italy;5. Department of Biology, Faculty of Science, Atatürk University, Erzurum, Turkey |
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| Abstract: | Zinc borate is used as flame retardant for plastics and cellulose fibers, paper, rubber, and textiles. Despite its wide industrial use, there is limited information concerning its toxicity. The aim of the present study was to investigate the concentration dependence (0–280 mg L?1) of its genotoxic activity on cultured human lymphocytes by using sister chromatid exchange and chromosomal aberration assays. Total antioxidant capacity and the extent of oxidative stress were also determined. Zinc borate was found to be non-genotoxic at all tested concentrations. It exhibited antioxidant activity at concentrations lower than 40 mg L?1, and total oxidative stress levels were not changed at any applied concentration of zinc borate. |
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| Keywords: | zinc borate total antioxidant capacity oxidative stress sister chromatid exchange chromosomal aberration |
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