Effects of the Ellagic acid on the N‐Acetyltransferase activity and Acetylation of 2‐aminofluorene in the rat |
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| Authors: | Chin C Ho Huei Y Tsai Yih S Lai Jing G Chung |
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| Institution: | 1. Department of Physiology , China Medical College , 91 Hsueh‐Shih Road, Taichung, 400, Taiwan, Republic of China;2. Department of Pharmacology , China Medical College , 91 Hsueh‐Shih Road, Taichung, 400, Taiwan, Republic of China;3. Department of Pathology , China Medical College , 91 Hsueh‐Shih Road, Taichung, 400, Taiwan, Republic of China;4. Department of Microbiology , China Medical College , 91 Hsueh‐Shih Road, Taichung, 400, Taiwan, Republic of China |
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| Abstract: | The effects of the ellagic acid on the in vitro and in vivo acetylation of 2‐aminofluorene were investigated in male Sprague‐Dawley rats. For in vitro examination, cytosols with or without ellagic acid co‐treatment showed different percentage of 2‐aminofluorene acetylation. For in vivo examination, pre‐treatment of male rats with ellagic acid (10 mg/kg) 24h prior to the administration of 2‐aminofluorene (50 mg/kg) resulted in a 26% and 29%, respectively, decrease in the urinary and fecal recovery of N‐acetyl‐2‐aminofluorene, and a 37% decrease in the metabolic clearance of 2‐aminofluorene to N‐acetyl‐2‐aminofluorene. This is the first demonstration that ellagic acid decrease the N‐acetylation of carcinogens in vitro and in vivo. |
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| Keywords: | Ellagic acid acetylation 2‐aminofluorene carcinogenesis anti‐carcinogen |
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