Analysis of carcinogenic and mutagenic aromatic amines: An overview |
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Authors: | Lawrence Fishbein |
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Affiliation: | U.S. Department of Health, Education and Welfare, Food and Drug Administration , National Center for Toxicological Research , Jefferson, Arkansas, 72079, USA |
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Abstract: | The aromatic amines represent a category of considerable importance in terms of their broad industrial utilization per se as well as intermediates in the manufacture, of a wide variety of dyes which have been broadly used in textile, leather, plastic and paper products as well as in permanent and semi‐permanent coloring products. The exposure to these agents, a number of which are carcinogenic and/or mutagenic, can occur primarily via skin contact and inhalation and covers the spectrum of occupational, consumer and the general public. This overview will principally highlight a number of the recently applied methodologies (including GLC, HPLC, and SPF) for the analyses of benzidines, naphthylamines, aminobiphenyls, methylene bis(2‐chloro‐aniline); 2,4‐diaminotoluene and 2,4‐diaminoanisole with a focus on their determination in environmental and occupational samples. |
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Keywords: | Carcinogens Mutagens aromatic amines |
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