Metabolism and excretion of orally and intraperitoneally administered trimethylarsine oxide in the hamster |
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| Authors: | Hiroshi Yamauchi Keiko Takahashi Yukio Yamamura Toshikazu Kaise |
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| Institution: | 1. Department of Public Health , St. Marianna University School of Medicine , 2–16–1, Sugao, Miyamae‐ku, Kawasaki 213, Japan;2. Department of Food and Drug Science , Kanagawa Prefectural Public Health Laboratory 52–2 , Nakao‐cho, Asahi‐ku, Yokohama 241, Japan |
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| Abstract: | When trimethylarsine oxide (TMAO) was administered orally to hamsters once only, 86.9±11.1% of the administered dose of the compound was exreted in the urine during the following 24 hours: TMAO proved to be an arsenic compound eliminated extremely rapidly. The unchanged form of TMAO was the one and only trimethylarsenic compound (TMA) detected in the urine: in othe words, TMAO proved neither to be demethylated nor to be converted to arsenobetaine. It was shown, on the other hand, that TMAO is partly reduced in vivo and that only trimethylarsine was detected in expired air. |
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| Keywords: | PAHs retention index sediment |
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