Antispermatogenic effects of artemether: An animal model |
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| Authors: | A.S. Adekunle E.O. Agbedana O. Oyewopo A.L. Adedeji J.A. Adebisi |
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| Affiliation: | 1. Department of Biochemistry , Ladoke Akintola University of Technology , Ogbomoso, Nigeria kunleniran@yahoo.com;3. Department of Chemical Pathology , University of Ibadan , Ibadan, Nigeria;4. Department of Anatomy , Ladoke Akintola University of Technology , Ogbomoso, Nigeria;5. Department of Biochemistry , Ladoke Akintola University of Technology , Ogbomoso, Nigeria |
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| Abstract: | Various antimalarial drugs have been shown to exert different adverse effects; however, scanty information is available for artemether-induced potential side effects. The present study assessed effects of artemether on lipid profile, sperm count, and histological features of testes in an animal model. The mean total cholesterol, high-density lipoproteins, low-density lipoproteins, triglyceride, and total proteins in mice-administered artemether were higher compared with controls. The mean sperm counts in mice treated with artemether were reduced when compared with controls. In addition, it was observed that artemether affected the histopathology of seminiferous epithelia and Leydig cells. Evidence indicates that artemether exerts adverse effects in mice testes. |
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| Keywords: | artemether antimalaria lipid lipoproteins |
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